Here is a tip I stumbled on the other day.

When you have run your notes client for days, developed code, preview your code, hibernated your computer 5-6 times, used sametime, synchronized calendar data with you phone sometimes the client locks up on you.

Instead of manually trying to kill the processes you think Notes uses you can run:

nsd.exe -kill

So I have a desktop short cut to run it quickly and get back to being productive: